ADC 相關毒殺藥物關鍵材料

此表展示了我們一系列帶有不同類型抗癌藥物含 azide 官能基團之關鍵材料。可利用點擊化學快速與抗體或是小分子接合。

Payload Catalog No. Structure MW.
SN-38 ADC-SN-AZ-001
946.3668
SN-38 ADC-SN-AZ-010
906.3588
DM-1 ADC-DM-AZ-012
1293.383
DM-1 ADC-DM-AZ-022 1069.4233
DM-1 ADC-DM-AZ-023
1181.4798
DM-1 ADC-DM-AZ-025
1139.5016
DM-1 ADC-DM-AZ-027
1156.4463
DM-1 ADC-DM-AZ-029
1214.884
DM-1 ADC-DM-AZ-032
1137.4859
DM-1 ADC-DM-AZ-034
1137.3954
DM-1 ADC-DM-AZ-035
1131.439
Olaparib ADC-OL-AZ-038
708.3031
Olaparib ADC-OL-AZ-039
678.2926

分子探針關鍵材料

您可以一目了然地查看可用的螢光染料和反應基團組合。

Fluorophore ↓ Reactive group (R1) NHS esters Azides Carboxylic acids
Suggested reactive species
Abs(nm) | Em(nm)
amines
(peptides, proteins, amino-labeled DNA)
Ethynyl group, cycloalkynes
(click chemistry)
amines and alcohols
Rhodamine-B 546 | 567 na ADC-RH-AZ-007
ADC-RH-AZ-008
na
FITC 488 | 530 na ADC-D4-AZ-013 na
Cyanine 5 646 | 662 na ADC-C5-AZ-016 ADC-C5-CA-017
Dye 794 794 | 810 na na ADC-D7-CA-018
Dota (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid.) MRI | PET ADC-DT-NH-015 ADC-DT-AZ-009
ADC-DT-AZ-014
na

ADC / SMDC連接子

不同連接子雙端具有不同功能之官能基可供連接具有不同功能之小分子或是抗體。

Reactive group (R1) Reactive group (R2) → PNP esters Azides Carboxylic acids methyl ester NHS esters Other: disulfide, ketone
Suggested reactive species amines
(peptides, proteins, amino-labeled DNA)
Ethynyl group, cycloalkynes
(click chemistry)
amines and alcohols Protection of Carboxylic acid by Ester amines
(peptides, proteins, amino-labeled DNA)
thiol or amines….
Amine Electrophilic reagents
(like activated esters)
na ADC-AM-AZ-004 na ADC-AM-ME-020 na na
Azides Ethynyl group, cycloalkynes
(click chemistry)
na na ADC-AZ-CA-005
ADC-AZ-CA-006
ADC-AZ-CA-011
ADC-AZ-CA-021
ADC-AZ-CA-024
ADC-AZ-CA-026
ADC-AZ-CA-028
ADC-AZ-CA-030
ADC-AZ-CA-031
ADC-AZ-CA-033
ADC-AZ-CA-036
ADC-AZ-CA-041
ADC-AZ-CA-046
na ADC-AZ-NH-042 ADC-AZ-OT-050
Alkynes Azide group
(click chemistry)
ADC-AK-PN-037 na na na na ADC-AK-OT-048
Maleimides Sulfhydryl group
(peptides, proteins)
na ADC-MI-AZ-045 ADC-MI-CA-047
ADC-MI-CA-049
ADC-MI-ME-044 na na
NBoc Protection of primary amine by Boc na na ADC-NB-CA-019 na na na
9-Fluorenemethanol Fmoc protecting group na na na na ADC-9F-NH-043 na